General Information

  • ID:  hor004404
  • Uniprot ID:  P16224
  • Protein name:  Locustatachykinin-2
  • Gene name:  NA
  • Organism:  Locusta migratoria (Migratory locust)
  • Family:  Tachykinin family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Locusta (genus), Oedipodinae (subfamily), Acrididae (family), Acridoidea (superfamily), Acridomorpha, Acrididea (infraorder), Caelifera (suborder), Orthoptera (order), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  APLSGFYGVR
  • Length:  10(1-10)
  • Propeptide:  APLSGFYGVR
  • Signal peptide:  NA
  • Modification:  T10 Arginine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Myoactive peptide. Stimulates the contraction of the oviduct and foregut.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  NA
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004404_AF2.pdbhor004404_ESM.pdb

Physical Information

Mass: 122693 Formula: C50H75N13O13
Absent amino acids: CDEHIKMNQTW Common amino acids: G
pI: 9.35 Basic residues: 1
Polar residues: 4 Hydrophobic residues: 4
Hydrophobicity: 36 Boman Index: -283
Half-Life / Aliphatic Index: 4.4 hour Aliphatic Index: 78
Instability Index: 5237 Extinction Coefficient cystines: 1490
Absorbance 280nm: 165.56

Literature

  • PubMed ID:  2311766
  • Title:  Locustatachykinin I and II, two novel insect neuropeptides with homology to peptides of the vertebrate tachykinin family.